Targeting MuRF1 by small molecules in a HFpEF rat model improves myocardial diastolic function and skeletal muscle contractility

• Главные авторы: Volker Adams (Автор), Antje Schauer (Автор), Antje Augstein (Автор), Virginia Kirchhoff (Автор), Runa Draskowski (Автор), Anett Jannasch (Автор), Keita Goto (Автор), Gemma Lyall (Автор), Anita Männel (Автор), Peggy Barthel (Автор), Norman Mangner (Автор), Ephraim B. Winzer (Автор), Axel Linke (Автор), Siegfried Labeit (Автор)
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• Опубликовано: Wiley, 2022-06-01T00:00:00Z.
• Предметы: article
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Abstract Background About half of heart failure (HF) patients, while having preserved left ventricular function, suffer from diastolic dysfunction (so‐called HFpEF). No specific therapeutics are available for HFpEF in contrast to HF where reduced ejection fractions (HFrEF) can be treated pharmacolog...