Targeting MuRF1 by small molecules in a HFpEF rat model improves myocardial diastolic function and skeletal muscle contractility

• Main Authors: Volker Adams (Author), Antje Schauer (Author), Antje Augstein (Author), Virginia Kirchhoff (Author), Runa Draskowski (Author), Anett Jannasch (Author), Keita Goto (Author), Gemma Lyall (Author), Anita Männel (Author), Peggy Barthel (Author), Norman Mangner (Author), Ephraim B. Winzer (Author), Axel Linke (Author), Siegfried Labeit (Author)
• Format: Book
• Published: Wiley, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background About half of heart failure (HF) patients, while having preserved left ventricular function, suffer from diastolic dysfunction (so‐called HFpEF). No specific therapeutics are available for HFpEF in contrast to HF where reduced ejection fractions (HFrEF) can be treated pharmacolog...