QbD-based design and characterization of mucoadhesive microspheres of quetiapine fumarate with improved oral bioavailability and brain biodistribution potential

• Main Authors: Someshwar Komati (Author), Suryakanta Swain (Author), Muddana Eswara Bhanoji Rao (Author), Bikash Ranjan Jena (Author), Sambamoorthy Unnam (Author), Vishali Dasi (Author)
• Format: Book
• Published: Faculty of Pharmacy, Cairo University, 2018-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The present work aims to discuss on Quality by Design based development and characterization of the sustained release mucoadhesive microspheres of quetiapine fumarate. The microspheres were prepared by non-aqueous solvent evaporation process. Factor screening study was carried out using fractional f...