Angiotensin AT1-Receptor Blockers Enhance Cardiac Responses to Parasympathetic Nerve Stimulation via Presynaptic AT1 Receptors in Pithed Rats

Abstract.: In the present study, we investigated the effects of angiotensin AT1-receptor blockers, KT3-671 and losartan, on the cardiac vagal neurotransmission in pithed rats. The bradycardia induced by vagal nerve stimulation (VNS, at 5 Hz) was potentiated significantly and dose-dependently by KT3-...

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Main Authors: Fumiko Yamaki (Author), Takanori Arai (Author), Masato Aoyama (Author), Akane Watanabe (Author), Yoshinobu Takata (Author)
Format: Book
Published: Elsevier, 2013-01-01T00:00:00Z.
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