Functional evaluation of cyclosporine metabolism by CYP3A4 variants and potential drug interactions

• Main Authors: Qihui Kong (Author), Nanyong Gao (Author), Yahui Wang (Author), Guoxin Hu (Author), Jianchang Qian (Author), Bingbing Chen (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The aim of this study is to investigate the effects of CYP3A4 genetic polymorphisms on the metabolism of cyclosporine (CsA) in vitro and identify drugs that interact with CsA. An enzymatic incubation system was developed to evaluate the kinetic parameters of CYP3A4 on CsA catalysis. A total of 132 d...