Application of hot melt extrusion to enhance the dissolution and oral bioavailability of oleanolic acid

• Main Authors: Nannan Gao (Author), Mengran Guo (Author), Qiang Fu (Author), Zhonggui He (Author)
• Format: Bog
• Udgivet: Elsevier, 2017-01-01T00:00:00Z.
• Fag: article
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The aim of this study was to improve the in vitro dissolution rate and oral bioavailability of oleanolic acid (OA), a water insoluble drug belonging to BCS class IV. Hot melt extrusion (HME) was applied to develop OA amorphous solid dispersions. The characterizations of the optimal formulation were...