Biased anti-idiotype response in rabbits leads to high-affinity monoclonal antibodies to biologics

• Main Authors: Christina Großerichter-Wagener (Author), Dorien Kos (Author), Astrid van Leeuwen (Author), Lisanne Dijk (Author), Jorn Jeremiasse (Author), Floris C. Loeff (Author), Theo Rispens (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Antibody formation to human(ized) therapeutic antibodies in humans is highly skewed toward anti-idiotype responses, probably because the idiotype is the only 'foreign' part of the antibody molecule. Here, we analyzed antibody responses to F(ab')2 fragments of a panel of 17 human(ized)...