Permeation characteristics of tetracyclines in parallel artificial membrane permeation assay II: Effect of divalent metal ions and mucin

• मुख्य लेखकों: Sachika Yamauchi (लेखक), Daisuke Inoue (लेखक), Kiyohiko Sugano (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: International Association of Physical Chemists (IAPC), 2020-06-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

The bioavailability of tetracyclines is markedly decreased when co-administered with antacids, milk, or food containing Ca2+. Previously, it was suggested that the effective intestinal permeation of tetracycline (TC) was decreased due to Ca2+ linked mucin binding in the mucosal side. In the present...