Permeation characteristics of tetracyclines in parallel artificial membrane permeation assay II: Effect of divalent metal ions and mucin

The bioavailability of tetracyclines is markedly decreased when co-administered with antacids, milk, or food containing Ca2+. Previously, it was suggested that the effective intestinal permeation of tetracycline (TC) was decreased due to Ca2+ linked mucin binding in the mucosal side. In the present...

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Main Authors: Sachika Yamauchi (Author), Daisuke Inoue (Author), Kiyohiko Sugano (Author)
Format: Book
Published: International Association of Physical Chemists (IAPC), 2020-06-01T00:00:00Z.
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3rd Floor Main Library

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