Mapping Phosphodiesterase 4D (PDE4D) in Macaque Dorsolateral Prefrontal Cortex: Postsynaptic Compartmentalization in Layer III Pyramidal Cell Circuits

Mapping Phosphodiesterase 4D (PDE4D) in Macaque Dorsolateral Prefrontal Cortex: Postsynaptic Compartmentalization in Layer III Pyramidal Cell Circuits

cAMP signaling has powerful, negative effects on cognitive functions of the primate dorsolateral prefrontal cortex (dlPFC), opening potassium channels to reduce firing and impair working memory, and increasing tau phosphorylation in aging neurons. This contrasts with cAMP actions in classic circuits...

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Main Authors: Dibyadeep Datta (Author), John F. Enwright (Author), Dominique Arion (Author), Constantinos D. Paspalas (Author), Yury M. Morozov (Author), David A. Lewis (Author), Amy F. T. Arnsten (Author)
Format: Book
Published: Frontiers Media S.A., 2020-11-01T00:00:00Z.
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3rd Floor Main Library

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