In Vitro Metabolism and Transport Characteristics of Zastaprazan

• Main Authors: Min Seo Lee (Author), Jihoon Lee (Author), Minyoung Pang (Author), John Kim (Author), Hyunju Cha (Author), Banyoon Cheon (Author), Min-Koo Choi (Author), Im-Sook Song (Author), Hye Suk Lee (Author)
• Format: Book
• Published: MDPI AG, 2024-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Zastaprazan (JP-1366), a novel potassium-competitive acid blocker, is a new drug for the treatment of erosive esophagitis. JP-1366 is highly metabolized in human, mouse, and dog hepatocytes but moderately metabolized in rat and monkey hepatocytes when estimated from the metabolic stability of this c...