Amphotericin B resistance in Leishmania mexicana: Alterations to sterol metabolism and oxidative stress response.

• Hoofdauteurs: Edubiel A Alpizar-Sosa (Auteur), Nur Raihana Binti Ithnin (Auteur), Wenbin Wei (Auteur), Andrew W Pountain (Auteur), Stefan K Weidt (Auteur), Anne M Donachie (Auteur), Ryan Ritchie (Auteur), Emily A Dickie (Auteur), Richard J S Burchmore (Auteur), Paul W Denny (Auteur), Michael P Barrett (Auteur)
• Formaat: Boek
• Gepubliceerd in: Public Library of Science (PLoS), 2022-09-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Amphotericin B is increasingly used in treatment of leishmaniasis. Here, fourteen independent lines of Leishmania mexicana and one L. infantum line were selected for resistance to either amphotericin B or the related polyene antimicrobial, nystatin. Sterol profiling revealed that, in each resistant...