Amphotericin B resistance in Leishmania mexicana: Alterations to sterol metabolism and oxidative stress response.

• Main Authors: Edubiel A Alpizar-Sosa (Author), Nur Raihana Binti Ithnin (Author), Wenbin Wei (Author), Andrew W Pountain (Author), Stefan K Weidt (Author), Anne M Donachie (Author), Ryan Ritchie (Author), Emily A Dickie (Author), Richard J S Burchmore (Author), Paul W Denny (Author), Michael P Barrett (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Amphotericin B is increasingly used in treatment of leishmaniasis. Here, fourteen independent lines of Leishmania mexicana and one L. infantum line were selected for resistance to either amphotericin B or the related polyene antimicrobial, nystatin. Sterol profiling revealed that, in each resistant...