Close Functional Coupling Between Ca2+ Release-Activated Ca2+ Channels and Reactive Oxygen Species Production in Murine Macrophages

• Main Authors: Sheng-Wei Jin (Author), Li Zhang (Author), Qin-Quan Lian (Author), Shang-Long Yao (Author), Ping Wu (Author), Xiao-Yan Zhou (Author), Wei Xiong (Author), Du-Yun Ye (Author)
• Format: Book
• Published: Hindawi Limited, 2006-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aim. To investigate the role of Ca2+ release-activated Ca2+ (CRAC) channels in the ROS production in macrophages. Methods. The intracellular [Ca2+]i was analyzed by confocal laser microscopy. The production of ROS was assayed by flow cytometry. Results. Both LPS and thapsigargin induced an increase...