Chemokines (CCL3, CCL4, and CCL5) Inhibit ATP-Induced Release of IL-1β by Monocytic Cells

• Main Authors: Anca-Laura Amati (Author), Anna Zakrzewicz (Author), Kathrin Siebers (Author), Sigrid Wilker (Author), Sarah Heldmann (Author), Dariusz Zakrzewicz (Author), Andreas Hecker (Author), J. Michael McIntosh (Author), Winfried Padberg (Author), Veronika Grau (Author)
• Format: Book
• Published: Hindawi Limited, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Chemokines and ATP are among the mediators of inflammatory sites that can enter the circulation via damaged blood vessels. The main function of chemokines is leukocyte mobilization, and ATP typically triggers inflammasome assembly. IL-1β, a potent inflammasome-dependent cytokine of innate immunity,...