Alteration of the Retinoid Acid-CBP Signaling Pathway in Neural Crest Induction Contributes to Enteric Nervous System Disorder

• Main Authors: Cheng Li (Author), Rong Hu (Author), Nali Hou (Author), Yi Wang (Author), Zhili Wang (Author), Ting Yang (Author), Yan Gu (Author), Mulan He (Author), Yu Shi (Author), Jie Chen (Author), Weihong Song (Author), Tingyu Li (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Hirschsprung Disease (HSCR) and/or hypoganglionosis are common pediatric disorders that arise from developmental deficiencies of enteric neural crest cells (ENCCs). Retinoid acid (RA) signaling has been shown to affect neural crest (NC) development. However, the mechanisms underlying RA deficiency-i...