Effect of Roflumilast in airways disorders via dual inhibition of phosphodiesterase and Ca2+-channel

• Main Authors: Faisal Imam (Author), Najeeb Ur Rehman (Author), Mohd Nazam Ansari (Author), Wajhul Qamar (Author), Muhammad Afzal (Author), Khalid Saad Alharbi (Author)
• Format: Book
• Published: Elsevier, 2020-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The bronchodilator effects of Roflumilast "a selective phosphodiesterase type-4 (PDE4)" inhibitor studied in this experimental protocol. The spiral strips of isolated guinea-pig tracheal chains mounted in organ bath and maintained in Krebs solution ventilated with carbogen at 32 °C and in...