A novel marine-derived anti-acute kidney injury agent targeting peroxiredoxin 1 and its nanodelivery strategy based on ADME optimization

• Главные авторы: Ping Yu (Автор), Tanwei Gu (Автор), Yueyang Rao (Автор), Weimin Liang (Автор), Xi Zhang (Автор), Huanguo Jiang (Автор), Jindi Lu (Автор), Jianglian She (Автор), Jianmin Guo (Автор), Wei Yang (Автор), Yonghong Liu (Автор), Yingfeng Tu (Автор), Lan Tang (Автор), Xuefeng Zhou (Автор)
• Формат: ‌
• Опубликовано: Elsevier, 2024-07-01T00:00:00Z.
• Предметы: article
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Insufficient therapeutic strategies for acute kidney injury (AKI) necessitate precision therapy targeting its pathogenesis. This study reveals the new mechanism of the marine-derived anti-AKI agent, piericidin glycoside S14, targeting peroxiredoxin 1 (PRDX1). By binding to Cys83 of PRDX1 and augment...