A novel marine-derived anti-acute kidney injury agent targeting peroxiredoxin 1 and its nanodelivery strategy based on ADME optimization

• Main Authors: Ping Yu (Author), Tanwei Gu (Author), Yueyang Rao (Author), Weimin Liang (Author), Xi Zhang (Author), Huanguo Jiang (Author), Jindi Lu (Author), Jianglian She (Author), Jianmin Guo (Author), Wei Yang (Author), Yonghong Liu (Author), Yingfeng Tu (Author), Lan Tang (Author), Xuefeng Zhou (Author)
• Format: Book
• Published: Elsevier, 2024-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Insufficient therapeutic strategies for acute kidney injury (AKI) necessitate precision therapy targeting its pathogenesis. This study reveals the new mechanism of the marine-derived anti-AKI agent, piericidin glycoside S14, targeting peroxiredoxin 1 (PRDX1). By binding to Cys83 of PRDX1 and augment...