Pharmacological Characterization of the Microsomal Prostaglandin E2 Synthase-1 Inhibitor AF3485 In Vitro and In Vivo

Pharmacological Characterization of the Microsomal Prostaglandin E2 Synthase-1 Inhibitor AF3485 In Vitro and In Vivo

RationaleThe development of inhibitors of microsomal prostaglandin (PG)E2 synthase-1 (mPGES-1) was driven by the promise of attaining antiinflammatory agents with a safe cardiovascular profile because of the possible diversion of the accumulated substrate, PGH2, towards prostacyclin (PGI2).Objective...

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Main Authors: Luigia Di Francesco (Author), Annalisa Bruno (Author), Emanuela Ricciotti (Author), Stefania Tacconelli (Author), Melania Dovizio (Author), Paloma Guillem-Llobat (Author), Maria Alessandra Alisi (Author), Beatrice Garrone (Author), Isabella Coletta (Author), Giorgina Mangano (Author), Claudio Milanese (Author), Garret A. FitzGerald (Author), Paola Patrignani (Author)
Format: Book
Published: Frontiers Media S.A., 2020-04-01T00:00:00Z.
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3rd Floor Main Library

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