Drug Penetration into the Central Nervous System: Pharmacokinetic Concepts and In Vitro Model Systems

• Main Authors: Felix Neumaier (Author), Boris D. Zlatopolskiy (Author), Bernd Neumaier (Author)
• פורמט: ספר
• יצא לאור: MDPI AG, 2021-09-01T00:00:00Z.
• נושאים: article
• גישה מקוונת: Connect to this object online.

Delivery of most drugs into the central nervous system (CNS) is restricted by the blood-brain barrier (BBB), which remains a significant bottleneck for development of novel CNS-targeted therapeutics or molecular tracers for neuroimaging. Consistent failure to reliably predict drug efficiency based o...