Comparison Of Liver Cell Models Using The Basel Phenotyping Cocktail

• Main Authors: Benjamin Berger (Author), Massimiliano Donzelli (Author), Swarna Maseneni (Author), Franziska Boess (Author), Adrian Roth (Author), Stephan Krähenbühl (Author), Manuel Haschke (Author)
• Format: Book
• Published: Frontiers Media S.A., 2016-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Currently used hepatocyte cell systems for in vitro assessment of drug metabolism include hepatoma cell lines and primary human hepatocyte (PHH) cultures. We investigated the suit-ability of the validated in vivo Basel phenotyping cocktail (caffeine [CYP1A2], efavirenz [CYP2B6], losartan [CYP2C9], o...