Novel Luteolin-Loaded Chitosan Decorated Nanoparticles for Brain-Targeting Delivery in a Sporadic Alzheimer's Disease Mouse Model: Focus on Antioxidant, Anti-Inflammatory, and Amyloidogenic Pathways

• Main Authors: Haidy Abbas (Author), Nesrine S El Sayed (Author), Nancy Abdel Hamid Abou Youssef (Author), Passent M. E. Gaafar (Author), Mohamed R. Mousa (Author), Ahmed M. Fayez (Author), Manal A Elsheikh (Author)
• Format: Book
• Published: MDPI AG, 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Preparation and evaluation of a non-invasive intranasal luteolin delivery for the management of cognitive dysfunction in Alzheimer's disease (AD) using novel chitosan decorated nanoparticles. Development of luteolin-loaded chitosomes was followed by full in vitro characterization. In vivo effic...