Blonanserin extensively occupies rat dopamine D3 receptors at antipsychotic dose range

• Main Authors: Satoko Baba (Author), Takeshi Enomoto (Author), Tomoko Horisawa (Author), Takashi Hashimoto (Author), Michiko Ono (Author)
• Format: Book
• Published: Elsevier, 2015-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Antagonism of the dopamine D3 receptor has been hypothesized to be beneficial for schizophrenia cognitive deficits, negative symptoms and extrapyramidal symptoms. However, recent animal and human studies have shown that most antipsychotics do not occupy D3 receptors in vivo, despite their considerab...