The voltage-sensing domain of kv7.2 channels as a molecular target for epilepsy-causing mutations and anticonvulsants

• Hauptverfasser: Francesco eMiceli (Verfasst von), MariaVirginia eSoldovieri (Verfasst von), Fabio Arturo Iannotti (Verfasst von), Vincenzo eBarrese (Verfasst von), Paolo eAmbrosino (Verfasst von), Maria eMartire (Verfasst von), Maria Roberta Cilio (Verfasst von), Maurizio eTaglialatela (Verfasst von)
• Format: Buch
• Veröffentlicht: Frontiers Media S.A., 2011-02-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

Understanding the molecular mechanisms underlying voltage-dependent gating in voltage-gated ion channels (VGICs) has been a major effort over the last decades. In recent years, changes in the gating process have emerged as common denominators for several genetically-determined channelopathies affect...