The voltage-sensing domain of kv7.2 channels as a molecular target for epilepsy-causing mutations and anticonvulsants

• Egile Nagusiak: Francesco eMiceli (Egilea), MariaVirginia eSoldovieri (Egilea), Fabio Arturo Iannotti (Egilea), Vincenzo eBarrese (Egilea), Paolo eAmbrosino (Egilea), Maria eMartire (Egilea), Maria Roberta Cilio (Egilea), Maurizio eTaglialatela (Egilea)
• Formatua: Liburua
• Argitaratua: Frontiers Media S.A., 2011-02-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Understanding the molecular mechanisms underlying voltage-dependent gating in voltage-gated ion channels (VGICs) has been a major effort over the last decades. In recent years, changes in the gating process have emerged as common denominators for several genetically-determined channelopathies affect...