The voltage-sensing domain of kv7.2 channels as a molecular target for epilepsy-causing mutations and anticonvulsants

• Autori principali: Francesco eMiceli (Autore), MariaVirginia eSoldovieri (Autore), Fabio Arturo Iannotti (Autore), Vincenzo eBarrese (Autore), Paolo eAmbrosino (Autore), Maria eMartire (Autore), Maria Roberta Cilio (Autore), Maurizio eTaglialatela (Autore)
• Natura: Libro
• Pubblicazione: Frontiers Media S.A., 2011-02-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Understanding the molecular mechanisms underlying voltage-dependent gating in voltage-gated ion channels (VGICs) has been a major effort over the last decades. In recent years, changes in the gating process have emerged as common denominators for several genetically-determined channelopathies affect...