The voltage-sensing domain of kv7.2 channels as a molecular target for epilepsy-causing mutations and anticonvulsants

• Main Authors: Francesco eMiceli (Author), MariaVirginia eSoldovieri (Author), Fabio Arturo Iannotti (Author), Vincenzo eBarrese (Author), Paolo eAmbrosino (Author), Maria eMartire (Author), Maria Roberta Cilio (Author), Maurizio eTaglialatela (Author)
• Format: Book
• Published: Frontiers Media S.A., 2011-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Understanding the molecular mechanisms underlying voltage-dependent gating in voltage-gated ion channels (VGICs) has been a major effort over the last decades. In recent years, changes in the gating process have emerged as common denominators for several genetically-determined channelopathies affect...