Pre-miR-146a (rs2910164 G>C) single nucleotide polymorphism is genetically and functionally associated with leprosy.

• Main Authors: Paula F T Cezar- (Author), Thiago G Toledo-Pinto (Author), Carolinne S Marques (Author), Lucia E A Arnez (Author), Cynthia C Cardoso (Author), Luana T A Guerreiro (Author), Sérgio L G Antunes (Author), Márcia M Jardim (Author), Claudia de J F Covas (Author), Ximena Illaramendi (Author), Ida M Dias-Baptista (Author), Patrícia S Rosa (Author), Sandra M B Durães (Author), Antonio G Pacheco (Author), Marcelo Ribeiro-Alves (Author), Euzenir N Sarno (Author), Milton O Moraes (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2014-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Mycobacterium leprae infects macrophages and Schwann cells inducing a gene expression program to facilitate its replication and progression to disease. MicroRNAs (miRNAs) are key regulators of gene expression and could be involved during the infection. To address the genetic influence of miRNAs in l...