Uncovering the Therapeutic Potential of Lithium Chloride in Type 2 Diabetic Cardiomyopathy: Targeting Tau Hyperphosphorylation and TGF-β Signaling via GSK-3β Inhibition

• Main Authors: Layal Abou Assi (Author), Sahar Alkhansa (Author), Rachel Njeim (Author), Jaafar Ismail (Author), Mikel Madi (Author), Hilda E. Ghadieh (Author), Sarah Al Moussawi (Author), Tanya S. Azar (Author), Maurice Ayoub (Author), William S. Azar (Author), Sarah Hamade (Author), Rashad Nawfal (Author), Nina-Rossa Haddad (Author), Frederic Harb (Author), Wissam Faour (Author), Mahmoud I. Khalil (Author), Assaad A. Eid (Author)
• Format: Book
• Published: MDPI AG, 2024-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Diabetic cardiomyopathy (DCM) is a major complication of type 2 diabetes mellitus (T2DM) that leads to significant morbidity and mortality. The alteration in the signaling mechanism in diabetes leading to cardiomyopathy remains unclear. The purpose of this study is to investigate the role of tauopat...