Purified and Recombinant Hemopexin: Protease Activity and Effect on Neutrophil Chemotaxis

• Main Authors: Tian Lin (Author), Jialin Liu (Author), Feng Huang (Author), Tjitske S R van Engelen (Author), Sujatha R Thundivalappil (Author), Frank E Riley (Author), Michael Super (Author), Alexander L Watters (Author), Ann Smith (Author), Nathan Brinkman (Author), Donald E Ingber (Author), H Shaw Warren (Author)
• Format: Book
• Published: BMC, 2016-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Infusion of the heme-binding protein hemopexin has been proposed as a novel approach to decrease heme-induced inflammation in settings of red blood cell breakdown, but questions have been raised as to possible side effects related to protease activity and inhibition of chemotaxis. We evalua...