Oral administration of GW788388, an inhibitor of transforming growth factor beta signaling, prevents heart fibrosis in Chagas disease.

• Main Authors: Fabiane L de Oliveira (Author), Tania C Araújo-Jorge (Author), Elen M de Souza (Author), Gabriel M de Oliveira (Author), Wim M Degrave (Author), Jean-Jacques Feige (Author), Sabine Bailly (Author), Mariana C Waghabi (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND: Chagas disease induced by Trypanosoma cruzi (T. cruzi) infection is a major cause of mortality and morbidity affecting the cardiovascular system for which presently available therapies are largely inadequate. Transforming Growth Factor beta (TGFß) has been involved in several regulatory...