The mitochondrial fission protein Drp1 in liver is required to mitigate NASH and prevents the activation of the mitochondrial ISR

• Main Authors: Janos Steffen (Author), Jennifer Ngo (Author), Sheng-Ping Wang (Author), Kevin Williams (Author), Henning F. Kramer (Author), George Ho (Author), Carlos Rodriguez (Author), Krishna Yekkala (Author), Chidozie Amuzie (Author), Russell Bialecki (Author), Lisa Norquay (Author), Andrea R. Nawrocki (Author), Mark Erion (Author), Alessandro Pocai (Author), Orian S. Shirihai (Author), Marc Liesa (Author)
• Format: Book
• Published: Elsevier, 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: The mitochondrial fission protein Drp1 was proposed to promote NAFLD, as inhibition of hepatocyte Drp1 early in life prevents liver steatosis induced by high-fat diet in mice. However, whether Drp1-knockdown in older mice can reverse established NASH is unknown. Methods: N-acetylgalactosa...