Efficient simulation of clinical target response surfaces

• Main Authors: Daniel Lill (Author), Anne Kümmel (Author), Venelin Mitov (Author), Daniel Kaschek (Author), Nathalie Gobeau (Author), Henning Schmidt (Author), Jens Timmer (Author)
• Format: Book
• Published: Wiley, 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Simulation of combination therapies is challenging due to computational complexity. Either a simple model is used to simulate the response for many combinations of concentration to generate a response surface but parameter variability and uncertainty are neglected and the concentrations are...