Solubility-pH profiles of a free base and its salt: sibutramine as a case study

In the present study the solubility-pH profiles of sibutramine free base and its hydrochloride salt were determined in the pH range between 2.0 and 9.5 by means of the recommended shake-flask method, and the solids collected were dried and studied by X-ray diffraction in order to elucidate their fre...

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Main Authors: Diego Lucero-Borja (Author), Òscar Castilla (Author), Rafel Barbas (Author), Xavier Subirats (Author), Clara Ràfols (Author)
Format: Book
Published: International Association of Physical Chemists (IAPC), 2017-12-01T00:00:00Z.
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