Unambiguous identification of α-Gal epitopes in intact monoclonal antibodies by NMR spectroscopy

• Main Authors: Arthur Hinterholzer (Author), Jennifer Moises (Author), Christof Regl (Author), Sebastian Schwap (Author), Erdmann Rapp (Author), Christian G. Huber (Author), Mario Schubert (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The α-Gal epitope consisting of the terminal trisaccharide Galα1,3Galβ1,4GlcNAc exposed on cell or protein surfaces can cause severe immune reactions, such as hypersensitivity reactions, in humans. This epitope is also called the xenotransplantation epitope because it is one of the main reasons for...