IgA polymerization contributes to efficient virus neutralization on human upper respiratory mucosa after intranasal inactivated influenza vaccine administration

• Main Authors: Yoshihiko Terauchi (Author), Kaori Sano (Author), Akira Ainai (Author), Shinji Saito (Author), Yuki Taga (Author), Kiyoko Ogawa-Goto (Author), Shin-ichi Tamura (Author), Takato Odagiri (Author), Masato Tashiro (Author), Mikiya Fujieda (Author), Tadaki Suzuki (Author), Hideki Hasegawa (Author)
• Format: Book
• Published: Taylor & Francis Group, 2018-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Unlike the current injectable influenza vaccines, intranasally administered influenza vaccines induce influenza virus-specific IgA antibodies in the local respiratory mucosa as well as IgG antibodies in the systemic circulation. Our previous study showed that after five volunteers underwent intranas...