Advances and challenges in therapeutic monoclonal antibodies drug development

• Main Authors: Mariana Lopes dos Santos (Author), Wagner Quintilio (Author), Tania Maria Manieri (Author), Lilian Rumi Tsuruta (Author), Ana Maria Moro (Author)
• Format: Book
• Published: Universidade de São Paulo, 2018-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The use of serum containing polyclonal antibodies from animals immunized with toxins marked the beginning of the application of antibody-based therapy in late nineteenth century. Advances in basic research led to the development of the hybridoma technology in 1975. Eleven years later, the first ther...