DNA topoisomerase inhibition with the HIF inhibitor acriflavine promotes transcription of lncRNAs in endothelial cells

• Main Authors: Sandra Seredinski (Author), Frederike Boos (Author), Stefan Günther (Author), James A. Oo (Author), Timothy Warwick (Author), Judit Izquierdo Ponce (Author), Felix F. Lillich (Author), Ewgenij Proschak (Author), Stefan Knapp (Author), Ralf Gilsbach (Author), Beatrice Pflüger-Müller (Author), Ralf P. Brandes (Author), Matthias S. Leisegang (Author)
• Format: Book
• Published: Elsevier, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The transcription factor hypoxia-inducible factor 1 (HIF1) is an important driver of cancer and is therefore an attractive drug target. Acriflavine (ACF) has been suggested to inhibit HIF1, but its mechanism of action is unknown. Here we investigated the interaction of ACF with DNA and long non-codi...