The Botanical Drug PBI-05204, a Supercritical CO2 Extract of Nerium Oleander, Inhibits Growth of Human Glioblastoma, Reduces Akt/mTOR Activities, and Modulates GSC Cell-Renewal Properties

• Main Authors: Alessandro Colapietro (Author), Peiying Yang (Author), Alessandra Rossetti (Author), Andrea Mancini (Author), Flora Vitale (Author), Stefano Martellucci (Author), Tara L. Conway (Author), Sharmistha Chakraborty (Author), Francesco Marampon (Author), Vincenzo Mattei (Author), Giovanni Luca Gravina (Author), Assunta Leda Biordi (Author), Daoyan Wei (Author), Robert A. Newman (Author), Claudio Festuccia (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Glioblastoma multiform (GBM) is the most common primary glial tumor resulting in very low patient survival despite current extensive therapeutic efforts. Emerging evidence suggests that more effective treatments are required to overcome tumor heterogeneity, drug resistance and a complex tumor-suppor...