A point mutation in the Pdia6 gene results in loss of pancreatic β-cell identity causing overt diabetes

• Principais autores: Nirav Florian Chhabra (Autor), Anna-Lena Amend (Autor), Aimée Bastidas-Ponce (Autor), Sibylle Sabrautzki (Autor), Marta Tarquis-Medina (Autor), Stephan Sachs (Autor), Marina Rubey (Autor), Bettina Lorenz-Depiereux (Autor), Annette Feuchtinger (Autor), Mostafa Bakhti (Autor), Heiko Lickert (Autor), Gerhard K.H. Przemeck (Autor), Martin Hrabě de Angelis (Autor)
• Formato: Livro
• Publicado em: Elsevier, 2021-12-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Objective: Protein disulfide isomerases (PDIs) are oxidoreductases that are involved in catalyzing the formation and rearrangement of disulfide bonds during protein folding. One of the PDI members is the PDI-associated 6 (PDIA6) protein, which has been shown to play a vital role in β-cell dysfunctio...