Liver lobe-specific hydrodynamic gene delivery to baboons: A preclinical trial for hemophilia gene therapy

• المؤلفون الرئيسيون: Kenya Kamimura (مؤلف), Tsutomu Kanefuji (مؤلف), Takeshi Suda (مؤلف), Takeshi Yokoo (مؤلف), Guisheng Zhang (مؤلف), Yutaka Aoyagi (مؤلف), Dexi Liu (مؤلف)
• التنسيق: كتاب
• منشور في: Elsevier, 2023-06-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Hydrodynamics-based gene transfer has been successfully employed for in vivo gene delivery to the liver of small animals by tail vein injection and of large animals using a computer-assisted and image-guided protocol. In an effort to develop a hydrodynamic gene delivery procedure clinically applicab...