Liver lobe-specific hydrodynamic gene delivery to baboons: A preclinical trial for hemophilia gene therapy

• Main Authors: Kenya Kamimura (Author), Tsutomu Kanefuji (Author), Takeshi Suda (Author), Takeshi Yokoo (Author), Guisheng Zhang (Author), Yutaka Aoyagi (Author), Dexi Liu (Author)
• Format: Book
• Published: Elsevier, 2023-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Hydrodynamics-based gene transfer has been successfully employed for in vivo gene delivery to the liver of small animals by tail vein injection and of large animals using a computer-assisted and image-guided protocol. In an effort to develop a hydrodynamic gene delivery procedure clinically applicab...