Sirtuin 1 activator alleviated lethal inflammatory injury via promotion of autophagic degradation of pyruvate kinase M2

• Main Authors: Shuang Zhao (Author), Yili Sun (Author), Xicheng Wu (Author), Yongqiang Yang (Author), Kerui Fan (Author), Kai Hu (Author), Yasha Qin (Author), Kexin Li (Author), Ling Lin (Author), Kun Chen (Author), Yuhua Ma (Author), Min Zhu (Author), Gang Liu (Author), Li Zhang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Upregulation of pyruvate kinase M2 (PKM2) is critical for the orchestration of metabolism and inflammation in critical illness, while autophagic degradation is a recently revealed mechanism that counter-regulates PKM2. Accumulating evidence suggests that sirtuin 1 (SIRT1) function as a crucial regul...