Inhibiting Sphingosine Kinase 2 Derived-sphingosine-1-phosphate Ameliorates Psoriasis-like Skin Disease via Blocking Th17 Differentiation of Naïve CD4 T Lymphocytes in Mice

• Main Authors: Sun-Hye Shin (Author), Kyung-Ah Cho (Author), Soojung Hahn (Author), Younghay Lee (Author), Yu-He Kim (Author), So-Youn Woo (Author), Kyung-Ha Ryu (Author), Woo-Jae Park (Author), Joo-Won Park (Author)
• Format: Book
• Published: Medical Journals Sweden, 2019-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Sphingosine-1-phosphate (S1P) is a signalling sphingolipid metabolite that regulates important cell processes, including cell proliferation and apoptosis. Circulating S1P levels have been reported to be increased in patients with psoriasis relative to healthy patients. The aim of this study was to e...