Esculetin Provides Neuroprotection against Mutant Huntingtin-Induced Toxicity in Huntington's Disease Models

Esculetin Provides Neuroprotection against Mutant Huntingtin-Induced Toxicity in Huntington's Disease Models

Huntington's disease (HD) is a neurodegenerative disorder caused by an abnormal CAG trinucleotide repeat expansion within exon 1 of the huntingtin (HTT) gene. This mutation leads to the production of mutant HTT (mHTT) protein which triggers neuronal death through several mechanisms. Here, we in...

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Main Authors: Letizia Pruccoli (Author), Carlo Breda (Author), Gabriella Teti (Author), Mirella Falconi (Author), Flaviano Giorgini (Author), Andrea Tarozzi (Author)
Format: Book
Published: MDPI AG, 2021-10-01T00:00:00Z.
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