Novel Alligator Cathelicidin As-CATH8 Demonstrates Anti-Infective Activity against Clinically Relevant and Crocodylian Bacterial Pathogens

• Main Authors: Felix L. Santana (Author), Karel Estrada (Author), Morgan A. Alford (Author), Bing C. Wu (Author), Melanie Dostert (Author), Lucas Pedraz (Author), Noushin Akhoundsadegh (Author), Pavneet Kalsi (Author), Evan F. Haney (Author), Suzana K. Straus (Author), Gerardo Corzo (Author), Robert E. W. Hancock (Author)
• Format: Book
• Published: MDPI AG, 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Host defense peptides (HDPs) represent an alternative way to address the emergence of antibiotic resistance. Crocodylians are interesting species for the study of these molecules because of their potent immune system, which confers high resistance to infection. Profile hidden Markov models were used...