Chloroquine Attenuates Asthma Development by Restoring Airway Smooth Muscle Cell Phenotype Via the ROS-AKT Pathway

• Glavni autori: Yan Ren (Autor), Xiuhua Zhong (Autor), Hongyu Wang (Autor), Zhongqi Chen (Autor), Yanan Liu (Autor), Xiaoning Zeng (Autor), Yuan Ma (Autor)
• Format: Knjiga
• Izdano: Frontiers Media S.A., 2022-06-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

Switching of airway smooth muscle (ASM) cell phenotype from differentiated-contractile to dedifferentiated-proliferative/synthetic state often occurs in asthmatic subjects with airway dysfunction. Evidence has been provided that chloroquine (an agonist of bitter taste receptors) presented benefits t...