Spheroid Size Does not Impact Metabolism of the β-blocker Propranolol in 3D Intestinal Fish Model

• Main Authors: Laura M. Langan (Author), Stewart F. Owen (Author), Maciej Trznadel (Author), Nicholas J. F. Dodd (Author), Simon K. Jackson (Author), Wendy M. Purcell (Author), Awadhesh N. Jha (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Compared to two-dimensional (2D) cell culture, cellular aggregates or spheroids (3D) offer a more appropriate alternative in vitro system where individual cell-cell communication and micro-environment more closely represent the in vivo organ; yet we understand little of the physiological conditions...