A PDX1-ATF transcriptional complex governs β cell survival during stress

• Main Authors: Christine A. Juliana (Author), Juxiang Yang (Author), Corey E. Cannon (Author), Austin L. Good (Author), Matthew W. Haemmerle (Author), Doris A. Stoffers (Author)
• Format: Book
• Published: Elsevier, 2018-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Loss of insulin secretion due to failure or death of the insulin secreting β cells is the central cause of diabetes. The cellular response to stress (endoplasmic reticulum (ER), oxidative, inflammatory) is essential to sustain normal β cell function and survival. Pancreatic and duodenal h...