A PDX1-ATF transcriptional complex governs β cell survival during stress

• Glavni autori: Christine A. Juliana (Autor), Juxiang Yang (Autor), Corey E. Cannon (Autor), Austin L. Good (Autor), Matthew W. Haemmerle (Autor), Doris A. Stoffers (Autor)
• Format: Knjiga
• Izdano: Elsevier, 2018-11-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

Objective: Loss of insulin secretion due to failure or death of the insulin secreting β cells is the central cause of diabetes. The cellular response to stress (endoplasmic reticulum (ER), oxidative, inflammatory) is essential to sustain normal β cell function and survival. Pancreatic and duodenal h...