A Versatile Class of 1,4,4-Trisubstituted Piperidines Block Coronavirus Replication In Vitro

• Egile Nagusiak: Sonia De Castro (Egilea), Annelies Stevaert (Egilea), Miguel Maldonado (Egilea), Adrien Delpal (Egilea), Julie Vandeput (Egilea), Benjamin Van Loy (Egilea), Cecilia Eydoux (Egilea), Jean-Claude Guillemot (Egilea), Etienne Decroly (Egilea), Federico Gago (Egilea), Bruno Canard (Egilea), Maria-Jose Camarasa (Egilea), Sonsoles Velázquez (Egilea), Lieve Naesens (Egilea)
• Formatua: Liburua
• Argitaratua: MDPI AG, 2022-08-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

There is a clear need for novel antiviral concepts to control SARS-CoV-2 infection. Based on the promising anti-coronavirus activity observed for a class of 1,4,4-trisubstituted piperidines, we here conducted a detailed analysis of the structure-activity relationship of these structurally unique inh...