Assessment of glibenclamide pharmacokinetics in poloxamer 407-induced hyperlipidemic rats

• Main Authors: Yousef A. Bin Jardan (Author), Abdul Ahad (Author), Mohammad Raish (Author), Ajaz Ahmad (Author), Mohd Aftab Alam (Author), Abdullah M. Al-Mohizea (Author), Fahad I. Al-Jenoobi (Author)
• Format: Book
• Published: Elsevier, 2021-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The aim of the present research was to describe the consequences of hyperlipidemia (HL) on the pharmacokinetics of glibenclamide (Gb) in poloxamer 407-induced hyperlipidemic rats. Rats were given intraperitoneal dose of poloxamer 407 to cause hyperlipidemia. A single oral dose of Gb (10 mg/Kg) was g...