TRPM8 Activation via 3-Iodothyronamine Blunts VEGF-Induced Transactivation of TRPV1 in Human Uveal Melanoma Cells

• Main Authors: Lia Walcher (Author), Clara Budde (Author), Arina Böhm (Author), Peter S. Reinach (Author), Priyavathi Dhandapani (Author), Nina Ljubojevic (Author), Markus W. Schweiger (Author), Henriette von der Waydbrink (Author), Ilka Reimers (Author), Josef Köhrle (Author), Stefan Mergler (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In human uveal melanoma (UM), tumor enlargement is associated with increases in aqueous humor vascular endothelial growth factor-A (VEGF-A) content that induce neovascularization. 3-Iodothyronamine (3-T1AM), an endogenous thyroid hormone metabolite, activates TRP melastatin 8 (TRPM8), which blunts T...