Dexamethasone Promotes a Stem-Like Phenotype in Human Melanoma Cells via Tryptophan 2,3 Dioxygenase

• Main Authors: Marta Cecchi (Author), Antonella Mannini (Author), Andrea Lapucci (Author), Angela Silvano (Author), Matteo Lulli (Author), Cristina Luceri (Author), Mario D'Ambrosio (Author), Alberto Chiarugi (Author), Ali H. Eid (Author), Astrid Parenti (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In addition to its well-established immunosuppressive actions, tryptophan 2,3-dioxygenase (TDO) appears to elicit direct effects on tumor cell function. Although TDO has been associated with cancer stemness, its involvement in melanoma stem cell biology remains largely unknown. Since we showed that...