Mevalonate improves anti-PD-1/PD-L1 efficacy by stabilizing CD274 mRNA

• Main Authors: Wenxin Zhang (Author), Xiaohui Pan (Author), Yanjun Xu (Author), Hongjie Guo (Author), Mingming Zheng (Author), Xi Chen (Author), Honghai Wu (Author), Fengming Luan (Author), Qiaojun He (Author), Ling Ding (Author), Bo Yang (Author)
• Format: Book
• Published: Elsevier, 2023-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Mevalonate metabolism plays an important role in regulating tumor growth and progression; however, its role in immune evasion and immune checkpoint modulation remains unclear. Here, we found that non-small cell lung cancer (NSCLC) patients with higher plasma mevalonate response better to anti-PD-(L)...