An unbiased silencing screen in muscle cells identifies miR-320a, miR-150, miR-196b, and miR-34c as regulators of skeletal muscle mitochondrial metabolism

• Main Authors: Dennis Dahlmans (Author), Alexandre Houzelle (Author), Pénélope Andreux (Author), Johanna A. Jörgensen (Author), Xu Wang (Author), Leon J. de Windt (Author), Patrick Schrauwen (Author), Johan Auwerx (Author), Joris Hoeks (Author)
• Format: Book
• Published: Elsevier, 2017-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Strategies improving skeletal muscle mitochondrial capacity are commonly paralleled by improvements in (metabolic) health. We and others previously identified microRNAs regulating mitochondrial oxidative capacity, but data in skeletal muscle are limited. Therefore, the present study aimed...