Genome-wide CRISPR screen identified a role for commander complex mediated ITGB1 recycling in basal insulin secretion

• Main Authors: Liu Yang (Author), Margret A. Fye (Author), Bingyuan Yang (Author), Zihan Tang (Author), Yue Zhang (Author), Sander Haigh (Author), Brittney A. Covington (Author), Kai Bracey (Author), Justin W. Taraska (Author), Irina Kaverina (Author), Shen Qu (Author), Wenbiao Chen (Author)
• Format: Book
• Published: Elsevier, 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objectives: Pancreatic beta cells secrete insulin postprandially and during fasting to maintain glucose homeostasis. Although glucose-stimulated insulin secretion (GSIS) has been extensively studied, much less is known about basal insulin secretion. Here, we performed a genome-wide CRISPR/Cas9 knock...